Premo Guard Poultry Spray 32 oz - Kill Scaly Leg, Mites, Fleas, Lice on Chickens and in Coops Review (2026)

What it kills and how

Premo Guard Poultry Spray is built around natural clove oil and cottonseed oil rather than synthetic pesticides like permethrin. The maker states it is proven to kill on contact and is effective against mites including northern fowl mites and scaly leg mites, along with lice, fleas, and ticks, and that it works across all life stages of these pests including eggs and larvae. Because it targets the pest directly on contact, it fits into a routine where you spray during an active infestation and then continue on a lighter maintenance schedule once the population is under control, rather than a single one-time application.

Where you can use it

The spray is labeled for use directly on chickens, ducks, geese, turkeys, and other poultry, as well as on coops, roosts, nest boxes, pens, and outdoor runs. That dual use matters for mites in particular, since many species hide in cracks and roost bars during the day and only move onto birds at night, so treating just the bird or just the coop tends to leave a reservoir of pests behind. Being able to spray both the flock and their living space with one product simplifies a mite outbreak instead of needing a separate coop treatment and a separate bird-safe spray.

Safety and eggs

The maker states there is no egg withdrawal period required after using this spray, so eggs can keep being collected and eaten as normal during treatment. It is also described as safe around children and pets, with a natural clove scent rather than the harsh chemical smell of some conventional coop pesticides. The formula is marketed as veterinarian and farm approved and suitable for use on chicks as well as adult birds, which is a consideration since many synthetic treatments carry separate warnings or dosing for younger poultry. Avoiding a withdrawal period also means you do not need to mark eggs or track a waiting window on the calendar the way you might with a stronger chemical treatment.

Bottle size and use rate

This is the 32 ounce size, sitting between the smaller 16 ounce bottle and the 128 ounce bulk jug in the maker's lineup. For a small coop with a handful of birds, 32 ounces should cover an active infestation and several weeks of maintenance spraying, but a larger flock, a bigger coop, or a severe outbreak that calls for daily spraying can go through a bottle this size quickly. Keepers with more than a small backyard flock, or anyone treating multiple coops, may find the bulk size a better long-term value even though the 32 ounce bottle costs less upfront and is easier to handle while spraying birds one at a time.

Bottom line

This is a solid choice for a keeper who wants a natural, no-withdrawal option for routine mite and lice control that can go on both birds and coop surfaces. It is well suited to prevention and to catching an infestation early, when regular spraying can keep numbers down. For a flock already dealing with a heavy, established infestation, plan on reapplying often in the first couple of weeks to catch newly hatched pests, and consider the larger bottle size if you are treating more than one coop or a bigger flock on a tight schedule. Pairing it with a dust bath for the flock's own natural grooming can help keep mite numbers down between sprayings too.

Frequently asked questions